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PREPARATION AND EVALUATION OF PH DEPENDENT CURCUMIN NANOPARTICLES FOR COLON DRUG DELIVERY

Abstract

The present study was aimed at designing pH-sensitive, polymeric nanoparticles (NPs) of curcumin. Curcumin is a polyphenolic compound obtained from Curcuma domestica (Zingiberaceae) that exhibit diverse pharmacological action including anti-inflammatory,antioxidant, antimicrobial, and anticarcinogenic activities. Nanoencapsulation in biodegradable polymers is a promising effort to improve curcumin bioavailability. Colon targeted drug delivery has gained great importance in treating local diseases including intestinal bowel disease. In this study, curcumin was encapsulated in biodegradable polymer Xanthan Gum via emulsification-solvent evaporation method. Eudragit S100 was used for pH sensitive drug delivery. Optimization of selected parameters including the type of solvent, stirring time, drug polymer ratio and centrifugation speed were performed to obtain polymeric NPs with optimum attributes.
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