AbstractOne of the most exploitable methods for drugs' transport across the skin is the use of vesicle formulation as skin delivery systems. Ethosomes are phospholipid-based elastic nanovesicles containing a content of ethanol ranging from 20–45%. Ethosomes are noninvasive delivery carriers that enable drugs to reach deep into the skin layers and/or the systemic circulation. These are soft, malleable vesicles tailored for enhanced delivery of active agents. In ethosomal formulations, both ethanol and phospholipids together enhance the skin permeation of the drugs. The high flexibility of vesicular membranes from the added ethanol permits the elastic vesicles to squeeze themselves through the pores, which are much smaller than their diameters. There are three different types of ethosomal systems. Due to the uniqness, there are various advantages of ethosomal drugdelivery system. Ethosomes are mainly considered as a as replacement of liposomes. Ethosomes can be used for thetransdermal delivery o fhydrophilic and impermeable drugs through the skin. Variousdrugs have been used with ethosomal carrier. The aim of the present review is to introduce the novel concept of ethosomes as a carrier for drug delivery in treatment of various diseases.