AbstractThe present study was designed for assessment of “Effect of Compliance Therapy for Antipsychotic Medication Adherence in People with Schizophrenia at Tertiary Care Institute.” This is an interventional study on 80 patients of schizophrenia, selected by a Quasi-random sampling technique over age group range of 14 to 66 years. Psychoeducation was given to the patients or patientsfamily members(if patientis Non-competent) in presence of psychiatrist. The data was collected at baseline and follow up visits of the patients & analyzed by SPSS software (Version 22.0).The overall compliance of psychoeducational armandNon-psychoeducational arm is 61%. Satisfactory compliance in psychoeducational arm is 100% but only 23 % in NonPsychoeducational arm. Highest number of patients who completed prescribed treatment and follow up schedule was in age group of 21 to 30 years in psychoeducational as well as Nonpsychoeducational arm. Male patients have more compliance to the study. Patients who don't have family history of psychotic disorder, they are more adhering to the study. It have seems that patients have addiction of tobacco (chewing or smoking) shows lower rate of compliance. This study suggests that psychoeducationas compliance therapy improves adherence to antipsychotic medicationas comparedtonon-psychoeducation.