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Anti-Clastogenic effect of Trigonella foenum graecum in mouse bone marrow cells

Abstract

Objective: Noticeable chromosomal damage or recombination is generally considered important aspect bringing change in heritable or character which involved in multi-step process of malignancy, where genetic changes plays significant role.
Methods: Inhibitory effects of Trigonella foenum graecum was evaluated on the induction of clastogenicity on bone marrow cells induced by Cyclophosphamide in mice, using Bone Marrow Chromosomal assay.
Results: Pre-treatment with methanolic and aqueous extract of Leaves of Trigonella foenum graecum (100 & 200mg/kg b.wt, p.o) reduced structural chromosomal aberrations scored significantly along with restoration of enzymatic antioxidants like Catalase, reduced glutathione and malonaldehyde content.
Conclusion: In conclusion, it was found that Trigonella foenum graecum reduces genotoxicity induced by Cyclophosphamide and thus may decrease the risk of development of secondary tumor.
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